Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines

Over the last few years, conventional medicine has been increasingly moving towards precision medicine. Today, production of oral pharmaceutical forms tailored to patients is not achievable by traditional industrial means. A promising solution customize drug delivery found in utilization 3D Printing and particular Fused Deposition Modeling (FDM). Thus, aim this systematic literature review provide a synthesis on solid using FDM technology. In total, 72 relevant articles have identified via two well-known scientific databases (PubMed ScienceDirect). Overall, three different methods reported: "Impregnation-FDM", “Hot Melt Extrusion coupled with FDM” "Print-fill", which yielded formulation thermoplastic polymers used as main component, five families other excipients playing functional roles 47 active ingredients. Solutions are underway overcome high printing temperatures, was initial brake use thermosensitive ingredients Also, moisture sensitivity shown large number prints preliminary storage studies highlighted. seems be especially fitted for treatment rare diseases, populations requiring doses or release kinetics. For future clinical trials, an implication health regulatory agencies would necessary. Hence, further efforts likely oriented quality approach such "Quality Design" could facilitate its approval authorities, also aid development technology manufacturers.